Here is a quick glance of all the highs and lows from Nadal's stupendous career:
Jannik Sinner secured the year-end world number one ranking by beating Czech 30th seed Tomas Machac in the Shanghai Masters semi-finals.
With no Nadal to defend his U.S. Open crown, on form, it's Djokovic's title for the taking, unless Federer shows glimpses of his past perfect self.
Novak Djokovic moved ahead for the first time in his long-running rivalry with Rafael Nadal when the World No 1 thrashed the Spaniard to win the Qatar Open in Doha on Saturday.
Madison Keys was dumped out of the Miami Open third round on Sunday, falling 6-4, 6-2 to Philippine wild card Alexandra Eala
Novak Djokovic joined the tennis greats on Sunday when he downed British second seed Andy Murray 3-6 6-1 6-2 6-4 to claim his maiden French Open title and hold all four grand slams at the same time. The world number one recovered from a nervous start to impose his pace on Court Philippe Chatrier and clinch his 12th grand slam crown after three previous failures in a Roland Garros final. Djokovic is only the third man after Don Budge and Rod Laver to hold the four majors at the same time, and the eighth man to triumph at Wimbledon and the French, U.S. and Australian Opens.
World No 1 Carlos Alcaraz fended off in-form American Tommy Paul to reach the Cincinnati Open quarter-finals on Thursday
Novak Djokovic looked to have regained his confidence and form just in time for a concerted Wimbledon assault as he carved out an emphatic win over Gael Monfils in the Aegon International grasscourt final at Eastbourne on Saturday.
Let battle commence, says Djokovic ahead of Nadal showdown
World No 1 Novak Djokovic will miss Serbia's Davis Cup World Group playoff tie against India in Bangalore next weekend, the Balkan nation's coach Bogdan Obradovic said on Monday.
Off-court distractions and a neck injury could not prevent Novak Djokovic from extending his winning run this year to 23 matches and the Serbian could not be in more intimidating form ahead of the US Open.
Jim Courier said Novak Djokovic's decision to work with so-called 'guru' Pepe Imaz was partly to blame for his shock defeat at Roland Garros on Wednesday.
Novak Djokovic clawed his way to a two sets to one lead over great rival Rafael Nadal before their scintillating Wimbledon semi-final was paused on a knife-edge on Friday.
World No 1 tennis player Novak Djokovic is set to reveal never before told stories about his life in a short documentary series in partnership with Australian winery Jacob's Creek.
Jannik Sinner defeated Carlos Alcaraz in a high-octane final to claim his maiden Wimbledon trophy and fourth Grand Slam crown on Sunday.
Another day, another milestone reached for Novak Djokovic as he racked up Grand Slam victory number 350.
The 'Big Three' of men's tennis have found some "fresh energy" to thwart the charge of younger players on the tour, world number one Novak Djokovic said after setting up yet another title clash against his biggest rival against Rafael Nadal.
Serbia's parliamentary speaker, Ivica Dacic, said on Monday he is concerned tennis star Novak Djokovic could still be deported from Australia despite winning his court case over his visa and vaccination exemption.
Novak Djokovic is finally set to return to action next week after six months out with an elbow injury and will then decide whether to take part in the Jan 15-28 Australian Open.
Novak Djokovic is arguably the best returner the game has ever seen, is the best athlete and has an engaging personality, there is only so much love to go around.
Novak Djokovic reasserted his rule over the hard-courts of Melbourne Park
The Dane revealed he had taken notes from how Novak Djokovic beat Alcaraz in the Olympic final at Roland Garros.
The prospect of winning an Olympic gold medal for Serbia outweighs the disappointment of playing in an empty venue at the Tokyo games, the men's world tennis number one Novak Djokovic said on Monday.
World No 1 Novak Djokovic continued his impressive run of form, winning the Miami Open over Andy Murray 7-6(3), 4-6, 6-0 at Key Biscayne on Sunday.
Djokovic will be nowhere near the centre court after losing his bid to overturn a second visa cancellation.
Novak Djokovic has sealed the year-end men's world number one tennis ranking for the sixth time to go level with childhood hero Pete Sampras after closest rival Rafael Nadal opted against playing in the ATP Tour event in Sofia next week.
Djokovic was soundly beaten by Zverev in the 2018 final, a match played out in an electrifying atmosphere in front of 18,000 fans. This time the arena was empty because of the COVID-19 lockdown, a surreal backdrop for a match with so much riding on it for both men.
World number one Novak Djokovic was disqualified from his US Open fourth round match against Pablo Carreno Busta on Sunday after the Serbian struck a line judge with a ball following a point.
World men's tennis No. 1 Novak Djokovic headed reluctantly home on Monday after being kicked out of Australia because of his COVID-19 unvaccinated status, but the government left the door open for a possible return to his favourite Grand Slam in 2023.
'Rarely did I feel my best on clay in the first or second tournament in the season. That was the case this season again. It took me two tournaments to really feel that I'm getting closer to the desired level.'
US Open Tournament Referee Soeren Friemel said there was "no other option" but to disqualify world number one Novak Djokovic on Sunday after he struck a line judge with a ball.
Sinner won in Cincinnati this week to claim his fifth title of a breakout season before the revelation that he avoided a ban over two positive tests
His Queen's run, plus a quarter-final at the French Open suggest Novaj Djokovic, who will climb back into the world's top 20 on Monday, is ready for a lengthy run at Wimbledon.
Three-time Wimbledon champion Novak Djokovic roared his way into the fourth round with a 6-4, 6-1, 7-6(2) defeat of unpredictable Latvian Ernests Gulbis on Centre Court.
His third straight triumph at the All England Club also earned the Serbian a 20th Grand Slam title
Djokovic was disqualified while trailing Spaniard Pablo Carreno Busta 6-5 in the opening set of their fourth-round tie on Sunday, striking a line judge with a petulant swipe of the ball.
Novak Djokovic launched his bid for a record seventh Australian Open title on Tuesday with an impressive 6-1, 7-6(4), 6-2 win over hard-hitting Spaniard Fernando Verdasco.
Novak Djokovic dredged his tank of mental and physical resilience to claim a thrilling 7-6(5), 1-6, 7-6(4), 4-6, 13-12(3) win.
Images from Day 2 of the 2023 Australian Open at Melbourne Park on Tuesday.
World number one Novak Djokovic has been "playing by his own rules" and has put his bid for a 21st Grand Slam title at risk by not following Australia's COVID-19 vaccination requirements, world number four Stefanos Tsitsipas said on Thursday.